Most B-vitamins on the market today share two design choices: they use methylated forms (methylfolate, methylcobalamin), and they come in mega-doses — often 1,000% to 10,000% of the daily value per nutrient. For many people, that combination works fine.
But research suggests that as many as 1 in 3 people don't tolerate methylated B-vitamins well — and an overlapping group can't handle the mega-doses either. Instead of more energy and clarity, they feel anxious, jittery, can't sleep, or get a headache within hours of taking them. Most never connect the dots — they assume the supplement just "didn't work for them" and move on.
This short self-check will help you figure out where you fall on the methylation sensitivity spectrum, and give you a personalized recommendation for what to do about it.